Neither side is better. For the same win chance, both cover the same number of results and pay the same multiplier. The targets just differ: a 49.5% chance is Under 49.50 (wins on 0.00-49.49) or Over 50.49 (wins on 50.50-99.99).
Some operators roll from 0.00 to 100.00 instead of 99.99, which shifts the Over targets slightly. Check the range your casino uses.
In ProvablyHero tools: the Dice odds table lists matching Under and Over targets.